Predictors of IDDM recurrence risk in offspring of Danish IDDM patients

Elevated levels of circulating adhesion molecules in IDDM patients and in subjects at risk for IDDM.

Serum levels of recently discovered circulating forms of adhesion molecules, ICAM-1 and L-selectin, were found to be elevated in IDDM patients and in subjects at risk for developing IDDM compared with 100 normal, nondiabetic blood donors. Both adhesion molecules were determined by sandwich ELISA. Serum concentrations of either clCAM-1 or cL-selectin were > 2SD of normal mean in 10 of 14 recent-...

Linkage and association between a CD4 gene polymorphism and IDDM in Danish IDDM patients. The Danish IDDM Epidemiology and Genetics Group, and The Danish Study Group of Diabetes in Childhood.

CD4+ T-cells play a central role in IDDM pathogenesis (1). Hence, gene polymorphisms that modulate the CD4 T-cell response to antigen presentation may confer susceptibility to IDDM. The CD4 receptor augments the CD4 T-cell receptor-mediated response to antigen presentation by interacting with major histocompatibility complex (MHC) class II molecules on antigen-presenting cells and the T-cell re...

IFN-gamma, IGIF, and IDDM.

IDDM, counterregulation, and the brain.

Health insurance and the financial impact of IDDM in families with a child with IDDM.

OBJECTIVE To examine the health insurance experience and out-of-pocket health care costs of families with a child with IDDM. RESEARCH DESIGN AND METHODS A case-control study of 197 families with a child with IDDM and 142 control families with no diabetic children was conducted. IDDM-affected families were identified from the Allegheny County IDDM Registry. Brothers and sisters of the parents ...